Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fn1  fibronectin 1   (Synonyms: Fn, Fn-1)
Results	Reference
1	J:178985 Alvarez JI, Dodelet-Devillers A, Kebir H, Ifergan I, Fabre PJ, Terouz S, Sabbagh M, Wosik K, Bourbonniere L, Bernard M, van Horssen J, de Vries HE, Charron F, Prat A, The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science. 2011 Dec 23;334(6063):1727-31
1	J:232500 Andrae J, Gouveia L, Gallini R, He L, Fredriksson L, Nilsson I, Johansson BR, Eriksson U, Betsholtz C, A role for PDGF-C/PDGFRalpha signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex. Biol Open. 2016;5(4):461-74
1*	J:50678 Appert A, Fridmacher V, Locquet O, Magre S, Patterns of keratins 8, 18 and 19 during gonadal differentiation in the mouse: sex- and time-dependent expression of keratin 19. Differentiation. 1998 Sep;63(5):273-84
1	J:73415 Arthur HM, Ure J, Smith AJ, Renforth G, Wilson DI, Torsney E, Charlton R, Parums DV, Jowett T, Marchuk DA, Burn J, Diamond AG, Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Dev Biol. 2000 Jan 1;217(1):42-53
1	J:126737 Astrof S, Crowley D, Hynes RO, Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Dev Biol. 2007 Nov 1;311(1):11-24
1	J:85994 Aszodi A, Hunziker EB, Brakebusch C, Fassler R, Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev. 2003 Oct 1;17(19):2465-79
1*	J:153111 Aufderheide E, Ekblom P, Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactions. J Cell Biol. 1988 Dec;107(6 Pt 1):2341-9
1	J:174103 Ayres-Silva Jde P, Manso PP, Madeira MR, Pelajo-Machado M, Lenzi HL, Sequential morphological characteristics of murine fetal liver hematopoietic microenvironment in Swiss Webster mice. Cell Tissue Res. 2011 Jun;344(3):455-69
1	J:152968 Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro AF, Sheppard D, Makinen T, Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell. 2009 Aug;17(2):175-86
1	J:240616 Benito-Jardon M, Klapproth S, Gimeno-LLuch I, Petzold T, Bharadwaj M, Muller DJ, Zuchtriegel G, Reichel CA, Costell M, The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes. Elife. 2017 Jan 16;6:e22264
1	J:221761 Bennett KM, Afanador MD, Lal CV, Xu H, Persad E, Legan SK, Chenaux G, Dellinger M, Savani RC, Dravis C, Henkemeyer M, Schwarz MA, Ephrin-B2 reverse signaling increases alpha5beta1 integrin-mediated fibronectin deposition and reduces distal lung compliance. Am J Respir Cell Mol Biol. 2013 Oct;49(4):680-7
1	J:340618 Bondarenko V, Nikolaev M, Kromm D, Belousov R, Wolny A, Blotenburg M, Zeller P, Rezakhani S, Hugger J, Uhlmann V, Hufnagel L, Kreshuk A, Ellenberg J, van Oudenaarden A, Erzberger A, Lutolf MP, Hiiragi T, Embryo-uterine interaction coordinates mouse embryogenesis during implantation. EMBO J. 2023 Sep 4;42(17):e113280
1	J:261197 Chen J, Van Gulden S, McGuire TL, Fleming AC, Oka C, Kessler JA, Peng CY, BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response. J Neurosci. 2018 Apr 11;38(15):3840-3857
1	J:239862 Coram RJ, Stillwagon SJ, Guggilam A, Jenkins MW, Swanson MS, Ladd AN, Muscleblind-like 1 is required for normal heart valve development in vivo. BMC Dev Biol. 2015 Oct 15;15:36
1	J:248815 Cordeiro OG, Chypre M, Brouard N, Rauber S, Alloush F, Romera-Hernandez M, Benezech C, Li Z, Eckly A, Coles MC, Rot A, Yagita H, Leon C, Ludewig B, Cupedo T, Lanza F, Mueller CG, Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL. PLoS One. 2016;11(3):e0151848
1	J:18222 Davis EC, Immunolocalization of microfibril and microfibril-associated proteins in the subendothelial matrix of the developing mouse aorta. J Cell Sci. 1994 Mar;107(Pt 3):727-36
1	J:126743 de Vega S, Iwamoto T, Nakamura T, Hozumi K, McKnight DA, Fisher LW, Fukumoto S, Yamada Y, TM14 is a new member of the fibulin family (fibulin-7) that interacts with extracellular matrix molecules and is active for cell binding. J Biol Chem. 2007 Oct 19;282(42):30878-88
1	J:121987 Derin BG, Erdogan D, Take G, Lortlar N, Immunohistochemical localization of extracellular matrix proteins in developing lung tissues. Saudi Med J. 2007 Mar;28(3):334-8
1	J:166772 DeRouen MC, Zhen H, Tan SH, Williams S, Marinkovich MP, Oro AE, Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. BMC Dev Biol. 2010;10:112
1	J:69569 DiPersio CM, Hodivala-Dilke KM, Jaenisch R, Kreidberg JA, Hynes RO, alpha3beta1 Integrin is required for normal development of the epidermal basement membrane. J Cell Biol. 1997 May 5;137(3):729-42
1	J:170886 Fujiwara H, Ferreira M, Donati G, Marciano DK, Linton JM, Sato Y, Hartner A, Sekiguchi K, Reichardt LF, Watt FM, The basement membrane of hair follicle stem cells is a muscle cell niche. Cell. 2011 Feb 18;144(4):577-89
1	J:115356 Griffin SV, Olivier JP, Pippin JW, Roberts JM, Shankland SJ, Cyclin I protects podocytes from apoptosis. J Biol Chem. 2006 Sep 22;281(38):28048-57
1	J:195895 Hanson KP, Jung JP, Tran QA, Hsu SP, Iida R, Ajeti V, Campagnola PJ, Eliceiri KW, Squirrell JM, Lyons GE, Ogle BM, Spatial and temporal analysis of extracellular matrix proteins in the developing murine heart: a blueprint for regeneration. Tissue Eng Part A. 2013 May;19(9-10):1132-43
1*	J:41399 Hardy MH, Vielkind U, Changing patterns of cell adhesion molecules during mouse pelage hair follicle development. 1. Follicle morphogenesis in wild-type mice. Acta Anat (Basel). 1996;157(3):169-82
1	J:221347 Hubmacher D, Wang LW, Mecham RP, Reinhardt DP, Apte SS, Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia - a novel mouse model providing insights into geleophysic dysplasia. Dis Model Mech. 2015 May 1;8(5):487-99
1	J:192400 Hunger C, Odemis V, Engele J, Expression and function of the SDF-1 chemokine receptors CXCR4 and CXCR7 during mouse limb muscle development and regeneration. Exp Cell Res. 2012 Oct 15;318(17):2178-90
1	J:75302 Iwaki T, Sandoval-Cooper MJ, Paiva M, Kobayashi T, Ploplis VA, Castellino FJ, Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse. Am J Pathol. 2002 Mar;160(3):1021-34
1	J:130822 Kanasaki K, Kanda Y, Palmsten K, Tanjore H, Lee SB, Lebleu VS, Gattone VH Jr, Kalluri R, Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Dev Biol. 2008 Jan 15;313(2):584-93
1*	J:37302 Kimata K, Sakakura T, Inaguma Y, Kato M, Nishizuka Y, Participation of two different mesenchymes in the developing mouse mammary gland: synthesis of basement membrane components by fat pad precursor cells. J Embryol Exp Morphol. 1985 Oct;89:243-57
1	J:71581 Kostka G, Giltay R, Bloch W, Addicks K, Timpl R, Fassler R, Chu ML, Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice. Mol Cell Biol. 2001 Oct;21(20):7025-34
1	J:250555 Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH, Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol. 2017 Mar;19(3):189-201
1	J:167114 Liang X, Sun Y, Ye M, Scimia MC, Cheng H, Martin J, Wang G, Rearden A, Wu C, Peterson KL, Powell HC, Evans SM, Chen J, Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation. 2009 Aug 18;120(7):568-76
1*	J:61486 Littlewood Evans A, Muller U, Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1. Nat Genet. 2000 Apr;24(4):424-8
1	J:263505 Liu G, Cooley MA, Jarnicki AG, Hsu AC, Nair PM, Haw TJ, Fricker M, Gellatly SL, Kim RY, Inman MD, Tjin G, Wark PA, Walker MM, Horvat JC, Oliver BG, Argraves WS, Knight DA, Burgess JK, Hansbro PM, Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases. JCI Insight. 2016 Jun 16;1(9):e86380
1	J:71108 Lozanoff S, Johnston J, Ma W, Jourdan-Le Saux C, Immunohistochemical localization of Pax2 and associated proteins in the developing kidney of mice with renal hypoplasia. J Histochem Cytochem. 2001 Sep;49(9):1081-97
1	J:195172 Ludtke TH, Farin HF, Rudat C, Schuster-Gossler K, Petry M, Barnett P, Christoffels VM, Kispert A, Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b. PLoS Genet. 2013 Jan;9(1):e1003189
1*	J:44769 Macauley SP, Tarnuzzer RW, Schultz GS, Chegini N, Oxford GE, Humphreys-Beher MG, Extracellular-matrix gene expression during mouse submandibular gland development. Arch Oral Biol. 1997 Jun;42(6):443-54
1	J:178484 Maddala R, Chauhan BK, Walker C, Zheng Y, Robinson ML, Lang RA, Rao PV, Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. Dev Biol. 2011 Dec 1;360(1):30-43
1	J:119922 Mailleux AA, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge JS, BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell. 2007 Feb;12(2):221-34
1	J:91587 Mates L, Nicolae C, Morgelin M, Deak F, Kiss I, Aszodi A, Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities. Matrix Biol. 2004 Jun;23(3):195-204
1	J:49019 Miosge N, Sasaki T, Chu ML, Herken R, Timpl R, Ultrastructural localization of microfibrillar fibulin-1 and fibulin-2 during heart development indicates a switch in molecular associations. Cell Mol Life Sci. 1998 Jun;54(6):606-13
1	J:232801 Misra A, Sheikh AQ, Kumar A, Luo J, Zhang J, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif DM, Integrin beta3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. J Exp Med. 2016 Mar 7;213(3):451-63
1*	J:201080 Nelson DA, Manhardt C, Kamath V, Sui Y, Santamaria-Pang A, Can A, Bello M, Corwin A, Dinn SR, Lazare M, Gervais EM, Sequeira SJ, Peters SB, Ginty F, Gerdes MJ, Larsen M, Quantitative single cell analysis of cell population dynamics during submandibular salivary gland development and differentiation. Biol Open. 2013 May 15;2(5):439-47
1*	J:13269 Ocklind G, Talts J, Fassler R, Mattsson A, Ekblom P, Expression of tenascin in developing and adult mouse lymphoid organs. J Histochem Cytochem. 1993 Aug;41(8):1163-9
1	J:142530 Pitera JE, Scambler PJ, Woolf AS, Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. Hum Mol Genet. 2008 Dec 15;17(24):3953-64
1	J:321441 Polanetzki V, Frob F, Baroti T, Schimmel M, Tamm ER, Wegner M, Role of the Pbrm1 subunit and the PBAF complex in Schwann cell development. Sci Rep. 2022 Feb 16;12(1):2651
1	J:156199 Robel S, Mori T, Zoubaa S, Schlegel J, Sirko S, Faissner A, Goebbels S, Dimou L, Gotz M, Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis. Glia. 2009 Nov 15;57(15):1630-47
1*	J:36890 Saga Y, Yagi T, Ikawa Y, Sakakura T, Aizawa S, Mice develop normally without tenascin. Genes Dev. 1992 Oct;6(10):1821-31
1	J:124110 Schmidt M, Paes K, De Maziere A, Smyczek T, Yang S, Gray A, French D, Kasman I, Klumperman J, Rice DS, Ye W, EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution. Development. 2007 Aug;134(16):2913-23
1	J:208341 Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B, Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
1*	J:18811 Sheppard AM, Onken MD, Rosen GD, Noakes PG, Dean DC, Expanding roles for alpha 4 integrin and its ligands in development. Cell Adhes Commun. 1994 Apr;2(1):27-43
1	J:127022 Shibata S, Dias RA, Hashimoto-Uoshima M, Abe T, Yanagishita M, Immunohistochemical localization of syndecan-1 in the dental follicle of postnatal mouse teeth. J Periodontol. 2007 Jul;78(7):1322-8
1	J:94926 Shiojiri N, Sugiyama Y, Immunolocalization of extracellular matrix components and integrins during mouse liver development. Hepatology. 2004 Aug;40(2):346-55
1	J:82152 Smeulders N, Woolf AS, Wilcox DT, Extracellular matrix protein expression during mouse detrusor development. J Pediatr Surg. 2003 Jan;38(1):1-12
1	J:199713 Somma G, Alger HM, McGuire RM, Kretlow JD, Ruiz FR, Yatsenko SA, Stankiewicz P, Harrison W, Funk E, Bergamaschi A, Oghalai JS, Mikos AG, Overbeek PA, Pereira FA, Head bobber: an insertional mutation causes inner ear defects, hyperactive circling, and deafness. J Assoc Res Otolaryngol. 2012 Jun;13(3):335-49
1	J:322612 Spina E, Simundza J, Incassati A, Chandramouli A, Kugler MC, Lin Z, Khodadadi-Jamayran A, Watson CJ, Cowin P, Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency. Nat Commun. 2022 Mar 17;13(1):1421
1	J:164924 Stimamiglio MA, Jimenez E, Silva-Barbosa SD, Alfaro D, Garcia-Ceca JJ, Munoz JJ, Cejalvo T, Savino W, Zapata A, EphB2-mediated interactions are essential for proper migration of T cell progenitors during fetal thymus colonization. J Leukoc Biol. 2010 Sep;88(3):483-94
1	J:151638 Su X, Paris M, Gi YJ, Tsai KY, Cho MS, Lin YL, Biernaskie JA, Sinha S, Prives C, Pevny LH, Miller FD, Flores ER, TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell. 2009 Jul 2;5(1):64-75
1	J:154910 Sugiyama Y, Akimoto K, Robinson ML, Ohno S, Quinlan RA, A cell polarity protein aPKClambda is required for eye lens formation and growth. Dev Biol. 2009 Dec 15;336(2):246-56
1	J:167396 Szabova L, Son MY, Shi J, Sramko M, Yamada SS, Swaim WD, Zerfas P, Kahan S, Holmbeck K, Membrane-type MMPs are indispensable for placental labyrinth formation and development. Blood. 2010 Dec 16;116(25):5752-61
1*	J:115860 Tada T, Widayati DT, Fukuta K, Morphological study of the transition of haematopoietic sites in the developing mouse during the peri-natal period. Anat Histol Embryol. 2006 Aug;35(4):235-40
1	J:227080 Taylor SH, Yeung CY, Kalson NS, Lu Y, Zigrino P, Starborg T, Warwood S, Holmes DF, Canty-Laird EG, Mauch C, Kadler KE, Matrix metalloproteinase 14 is required for fibrous tissue expansion. Elife. 2015;4:e09345
1	J:85775 Wagner TE, Frevert CW, Herzog EL, Schnapp LM, Expression of the integrin subunit alpha8 in murine lung development. J Histochem Cytochem. 2003 Oct;51(10):1307-15
1*	J:266595 Wartiovaara J, Leivo I, Vaheri A, Expression of the cell surface-associated glycoprotein, fibronectin, in the early mouse embryo. Dev Biol. 1979 Mar;69(1):247-57
1	J:141490 Welser JV, Lange ND, Flintoff-Dye N, Burkin HR, Burkin DJ, Placental defects in alpha7 integrin null mice. Placenta. 2007 Nov-Dec;28(11-12):1219-28
1	J:139011 Wilkinson GA, Schittny JC, Reinhardt DP, Klein R, Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity. Dev Dyn. 2008 Aug;237(8):2220-34
1	J:296772 Yin W, Kim HT, Wang S, Gunawan F, Li R, Buettner C, Grohmann B, Sengle G, Sinner D, Offermanns S, Stainier DYR, Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis. Eur Respir J. 2019 Mar;53(3)
1	J:150452 Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT, Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest. 2009 Jun;119(6):1462-76
1	J:70581 Zwijsen A, van Grunsven LA, Bosman EA, Collart C, Nelles L, Umans L, Van de Putte T, Wuytens G, Huylebroeck D, Verschueren K, Transforming growth factor beta signalling in vitro and in vivo: activin ligand-receptor interaction, Smad5 in vasculogenesis, and repression of target genes by the deltaEF1/ZEB-related SIP1 in the vertebrate embryo. Mol Cell Endocrinol. 2001 Jun 30;180(1-2):13-24